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linear maleimide-functionalized poly(ethylene glycol) peg-mi  (JenKem Inc)

 
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    Structured Review

    JenKem Inc linear maleimide-functionalized poly(ethylene glycol) peg-mi
    A) Reducing-microenvironment- or light-sensitive hydrogels were formed by reacting B) an aryl-thiol end <t>functionalized</t> poly(ethylene glycol) macromolecular precursor (PEG-4-MPA) or a photodegradable aryl-thiol end functionalized PEG (PEG-4-PD-MPA) with a <t>maleimide-end</t> functionalized PEG (PEG-2-MI) and a maleimide functionalized low molecular heparin (Heparin-MI) via a Michael-type reaction in an aqueous microenvironment. Low molecular weight proteins, such as growth factors (FGF-2 in the present study), cytokines, and immunomodulatory agents, can be incorporated within the hydrogel during network formation utilizing heparin-associated receptor-ligand interactions for protein retention. C) Aryl-thiol based succinimide thioether linkages exchange with free thiols in solution leading to the formation of a relatively stable alkyl-thiol (i.e., cysteine) based succinimide thioether linkage, resulting in hydrogel degradation. D) The photolabile o-nitrobenzyl moieties undergo irreversible photoisomerization in response to cytocompatible doses of long wavelength UV or visible light, yielding ketone and amide products.
    Linear Maleimide Functionalized Poly(ethylene Glycol) Peg Mi, supplied by JenKem Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/linear+maleimide-functionalized+poly(ethylene+glycol)+peg-mi/linear+maleimide+functionalized+poly+ethylene+glycol++peg+mi/pmc05806702-373-13-26
    Average 90 stars, based on 1 article reviews
    linear maleimide-functionalized poly(ethylene glycol) peg-mi - by Bioz Stars, 2026-10
    90/100 stars

    Images

    1) Product Images from "Controlling the release of small, bioactive proteins via dual mechanisms with therapeutic potential"

    Article Title: Controlling the release of small, bioactive proteins via dual mechanisms with therapeutic potential

    Journal: Advanced healthcare materials

    doi: 10.1002/adhm.201700713

    A) Reducing-microenvironment- or light-sensitive hydrogels were formed by reacting B) an aryl-thiol end functionalized poly(ethylene glycol) macromolecular precursor (PEG-4-MPA) or a photodegradable aryl-thiol end functionalized PEG (PEG-4-PD-MPA) with a maleimide-end functionalized PEG (PEG-2-MI) and a maleimide functionalized low molecular heparin (Heparin-MI) via a Michael-type reaction in an aqueous microenvironment. Low molecular weight proteins, such as growth factors (FGF-2 in the present study), cytokines, and immunomodulatory agents, can be incorporated within the hydrogel during network formation utilizing heparin-associated receptor-ligand interactions for protein retention. C) Aryl-thiol based succinimide thioether linkages exchange with free thiols in solution leading to the formation of a relatively stable alkyl-thiol (i.e., cysteine) based succinimide thioether linkage, resulting in hydrogel degradation. D) The photolabile o-nitrobenzyl moieties undergo irreversible photoisomerization in response to cytocompatible doses of long wavelength UV or visible light, yielding ketone and amide products.
    Figure Legend Snippet: A) Reducing-microenvironment- or light-sensitive hydrogels were formed by reacting B) an aryl-thiol end functionalized poly(ethylene glycol) macromolecular precursor (PEG-4-MPA) or a photodegradable aryl-thiol end functionalized PEG (PEG-4-PD-MPA) with a maleimide-end functionalized PEG (PEG-2-MI) and a maleimide functionalized low molecular heparin (Heparin-MI) via a Michael-type reaction in an aqueous microenvironment. Low molecular weight proteins, such as growth factors (FGF-2 in the present study), cytokines, and immunomodulatory agents, can be incorporated within the hydrogel during network formation utilizing heparin-associated receptor-ligand interactions for protein retention. C) Aryl-thiol based succinimide thioether linkages exchange with free thiols in solution leading to the formation of a relatively stable alkyl-thiol (i.e., cysteine) based succinimide thioether linkage, resulting in hydrogel degradation. D) The photolabile o-nitrobenzyl moieties undergo irreversible photoisomerization in response to cytocompatible doses of long wavelength UV or visible light, yielding ketone and amide products.

    Techniques Used: Molecular Weight

    Related Articles

    Molecular Weight:

    Article Title: Controlling the release of small, bioactive proteins via dual mechanisms with therapeutic potential
    Article Snippet: 4-arm amine-functionalized poly(ethylene glycol) (PEG-4-NH 2 , M n ~ 10,000 g/mol) and linear maleimide-functionalized poly(ethylene glycol) (PEG-MI, M n ~ 5,000 g/mol) were purchased from JenKem Technology USA Inc. (Allen, TX).



    Similar Products

    linear maleimide-functionalized poly(ethylene glycol) peg-mi  (JenKem Inc)
    90
    JenKem Inc linear maleimide-functionalized poly(ethylene glycol) peg-mi
    A) Reducing-microenvironment- or light-sensitive hydrogels were formed by reacting B) an aryl-thiol end <t>functionalized</t> poly(ethylene glycol) macromolecular precursor (PEG-4-MPA) or a photodegradable aryl-thiol end functionalized PEG (PEG-4-PD-MPA) with a <t>maleimide-end</t> functionalized PEG (PEG-2-MI) and a maleimide functionalized low molecular heparin (Heparin-MI) via a Michael-type reaction in an aqueous microenvironment. Low molecular weight proteins, such as growth factors (FGF-2 in the present study), cytokines, and immunomodulatory agents, can be incorporated within the hydrogel during network formation utilizing heparin-associated receptor-ligand interactions for protein retention. C) Aryl-thiol based succinimide thioether linkages exchange with free thiols in solution leading to the formation of a relatively stable alkyl-thiol (i.e., cysteine) based succinimide thioether linkage, resulting in hydrogel degradation. D) The photolabile o-nitrobenzyl moieties undergo irreversible photoisomerization in response to cytocompatible doses of long wavelength UV or visible light, yielding ketone and amide products.
    Linear Maleimide Functionalized Poly(ethylene Glycol) Peg Mi, supplied by JenKem Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/linear+maleimide-functionalized+poly(ethylene+glycol)+peg-mi/linear+maleimide+functionalized+poly+ethylene+glycol++peg+mi/pmc05806702-373-13-26
    Average 90 stars, based on 1 article reviews
    linear maleimide-functionalized poly(ethylene glycol) peg-mi - by Bioz Stars, 2026-10
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    A) Reducing-microenvironment- or light-sensitive hydrogels were formed by reacting B) an aryl-thiol end functionalized poly(ethylene glycol) macromolecular precursor (PEG-4-MPA) or a photodegradable aryl-thiol end functionalized PEG (PEG-4-PD-MPA) with a maleimide-end functionalized PEG (PEG-2-MI) and a maleimide functionalized low molecular heparin (Heparin-MI) via a Michael-type reaction in an aqueous microenvironment. Low molecular weight proteins, such as growth factors (FGF-2 in the present study), cytokines, and immunomodulatory agents, can be incorporated within the hydrogel during network formation utilizing heparin-associated receptor-ligand interactions for protein retention. C) Aryl-thiol based succinimide thioether linkages exchange with free thiols in solution leading to the formation of a relatively stable alkyl-thiol (i.e., cysteine) based succinimide thioether linkage, resulting in hydrogel degradation. D) The photolabile o-nitrobenzyl moieties undergo irreversible photoisomerization in response to cytocompatible doses of long wavelength UV or visible light, yielding ketone and amide products.

    Journal: Advanced healthcare materials

    Article Title: Controlling the release of small, bioactive proteins via dual mechanisms with therapeutic potential

    doi: 10.1002/adhm.201700713

    Figure Lengend Snippet: A) Reducing-microenvironment- or light-sensitive hydrogels were formed by reacting B) an aryl-thiol end functionalized poly(ethylene glycol) macromolecular precursor (PEG-4-MPA) or a photodegradable aryl-thiol end functionalized PEG (PEG-4-PD-MPA) with a maleimide-end functionalized PEG (PEG-2-MI) and a maleimide functionalized low molecular heparin (Heparin-MI) via a Michael-type reaction in an aqueous microenvironment. Low molecular weight proteins, such as growth factors (FGF-2 in the present study), cytokines, and immunomodulatory agents, can be incorporated within the hydrogel during network formation utilizing heparin-associated receptor-ligand interactions for protein retention. C) Aryl-thiol based succinimide thioether linkages exchange with free thiols in solution leading to the formation of a relatively stable alkyl-thiol (i.e., cysteine) based succinimide thioether linkage, resulting in hydrogel degradation. D) The photolabile o-nitrobenzyl moieties undergo irreversible photoisomerization in response to cytocompatible doses of long wavelength UV or visible light, yielding ketone and amide products.

    Article Snippet: 4-arm amine-functionalized poly(ethylene glycol) (PEG-4-NH 2 , M n ~ 10,000 g/mol) and linear maleimide-functionalized poly(ethylene glycol) (PEG-MI, M n ~ 5,000 g/mol) were purchased from JenKem Technology USA Inc. (Allen, TX).

    Techniques: Molecular Weight